![]() The related field of epigenetics aims to elucidate the role of specific epigenetic elements in biological processes, such as DNA methylation changes in diseases including cancer.Īgena BIOSCIENCE's MassARRAY® System is a powerful tool for downstream marker validation and large-scale agricultural research. Often referred to as “personalized medicine,” it is based on ascertaining the relevant variance of individuals versus average responses of whole populations. The relationship between a person’s genetic makeup and the way that person responds to and metabolizes drugs - plays an important role in healthcare today. Genomic biomarkers with potential clinical utility may be associated with disease state or therapeutic response, and include SNPs, somatic mutations, expressed RNA transcripts, DNA methylation regions, and copy number variations. Mutations play a key role as biomarkers for risk, progression, and prognosis. Genetic and somatic mutations can be employed to study their effect on oncogenesis, disease progression, or therapeutic response. Complex diseases, including cancer, cardiovascular disease, and neurological disorders, are often associated with multiple genetic and epigenetic factors, requiring flexible and customizable analysis tools. Identifying and studying genetic factors that contribute to disease requires sophisticated research tools and complex experimental designs.
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